CBN interacts with which cytochrome P-450 enzyme?

Cannabinoid compounds, such as cannabinol (CBN), interact with various cytochrome P-450 enzymes, which play a crucial role in drug metabolism in the liver. Specifically, CBN is known to interact significantly with both CYP-2C9 and CYP-3A4 enzymes.

CYP-2C9 is involved in the metabolism of a range of drugs and is known for its role in the breakdown of nonsteroidal anti-inflammatory drugs (NSAIDs) and anticoagulants. CYP-3A4 is particularly notable as it is responsible for the metabolism of nearly half of all clinically used medications, including many opioids and medications for chronic pain management.

This interaction is important in pain management because it can influence the efficacy and safety of co-administered medications. Understanding how CBN affects these enzymes can help clinicians anticipate potential drug interactions and adjust dosing accordingly to ensure effective pain relief while minimizing adverse effects.

The other options include different CYP enzymes that may play roles in drug metabolism, but they are not the primary enzymes affected by CBN, making the first choice the most accurate.