Delta-8 THC interacts with which cytochrome P-450 enzyme?

Delta-8 THC, like many cannabinoids, interacts with the cytochrome P-450 enzyme system, which plays a critical role in the metabolism of a wide variety of substances, including drugs and endocannabinoids. The correct response highlights that Delta-8 THC primarily influences both CYP-3A4 and CYP-1A2 enzymes.

CYP-3A4 is one of the most abundant enzymes in the liver and is involved in the metabolism of a significant number of medications and substances. The interaction of Delta-8 THC with this enzyme can affect the clearance rates of other drugs metabolized by CYP-3A4, which is important for understanding potential drug interactions and their clinical significance.

CYP-1A2 is also involved in the metabolism of several pharmaceuticals and substances. When Delta-8 THC interacts with this enzyme, it may influence the biotransformation processes, leading to altered effects of medications that rely on CYP-1A2 for their metabolism.

The inclusion of both enzymes as part of the correct answer emphasizes the complexity of cannabinoid interactions within the body and demonstrates the necessity for healthcare practitioners to be aware of how cannabinoids can affect drug metabolism to avoid unexpected side effects or therapeutic failures. Understanding these interactions is essential for ensuring safe and