What are the top 3 NSAIDs in terms of GI bleed risk from most to least?

The correct answer is based on the relative risk of gastrointestinal (GI) bleeding associated with non-steroidal anti-inflammatory drugs (NSAIDs). Ketorolac, Piroxicam, and Naproxen are known for their higher potential to cause GI bleeds compared to other NSAIDs, placing them at a greater risk in clinical settings.

Ketorolac is particularly noted for its strong analgesic effects and is often used post-operatively. However, it also has a significant risk of GI complications, especially when used inappropriately over extended periods. Piroxicam is a traditional NSAID that, while effective for inflammation, carries a higher risk of GI toxicity due to its long half-life and how it can induce mucosal damage. Naproxen, while considered safer than some other traditional NSAIDs, still poses a moderate risk for GI bleeding, particularly when used at higher doses or for prolonged periods.

When looking at the other options provided, they include NSAIDs like Celecoxib and Meloxicam, which are COX-2 selective inhibitors. These types of medications generally have a lower risk of GI bleeding compared to traditional NSAIDs, making them safer alternatives for patients with a history of GI issues. Additionally, other combinations listed contain medications