What is a primary reason for prescribing celecoxib instead of traditional NSAIDs?

Celecoxib is a selective COX-2 inhibitor, which primarily targets the cyclooxygenase-2 enzyme responsible for inflammation and pain, while sparing the COX-1 enzyme that protects the stomach lining. This selective action is a key reason celecoxib is often preferred over traditional non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit both COX-1 and COX-2 enzymes.

Traditional NSAIDs can lead to gastrointestinal complications, such as ulcers and bleeding, because they disrupt the protective mechanisms of the stomach. By contrast, celecoxib has a lower risk of causing these adverse gastrointestinal effects, making it a safer option for patients who may be at higher risk for such complications, such as the elderly or those with a history of GI problems.

While other factors such as cost, potency, and monitoring might play roles in medication selection, the primary and most clinically significant reason for choosing celecoxib over traditional NSAIDs is its lower risk of gastrointestinal side effects. This safety profile supports better patient adherence to treatment by reducing the likelihood of adverse reactions that could lead to discontinuation of therapy.