What is the only non-acid NSAID?

Nabumetone is recognized as the only non-acidic nonsteroidal anti-inflammatory drug (NSAID). The distinguishing feature of nabumetone is its pro-drug status; it's metabolized in the body to form an active compound that possesses anti-inflammatory properties. Unlike many other NSAIDs, which are acidic and can potentially lead to gastrointestinal irritation and other side effects, nabumetone has a neutral pH, which may contribute to a lower risk of such complications.

In contrast, NSAIDs like ibuprofen and aspirin are acidic and can cause gastric mucosal injury due to their mechanism of action, which involves the inhibition of cyclooxygenase enzymes that play a role in producing protective prostaglandins in the stomach lining. Celecoxib, although a selective COX-2 inhibitor and often viewed as having a different safety profile, is still classified as an acidic NSAID. Thus, nabumetone stands out in its formulation and potential side effect profile, making it an important option in pain management, particularly for patients who may be sensitive to the gastric effects of other NSAIDs.