What is the relative risk of overdose for 50-99 MME?

The relative risk of overdose for a morphine milligram equivalent (MME) dosage in the range of 50-99 is considered to be three times higher than at lower dosages. This reflects data from studies that show how increasing the dose of opioids correlates with an elevated risk of overdose.

The rationale behind this increase in relative risk is rooted in the pharmacological effects of opioids, which can depress the central nervous system. Higher dosages lead to greater respiratory depression, a primary cause of overdose, and also increase the likelihood of tolerance and dependence. As patients are prescribed opioids in the 50-99 MME range, they may also be more likely to misuse or experience adverse side effects, adding to the complexity and risk surrounding their use.

This increase in risk at specific dosage thresholds serves as critical guidance for healthcare providers in managing opioid therapy, emphasizing the need for careful monitoring and consideration of alternative pain management strategies as the dosage increases.