What is the risk of overdose death for MME 50-99?

In the context of opioid prescribing, the concept of morphine milligram equivalents (MME) is crucial for understanding the risk of overdose. When the MME reaches levels between 50 and 99, research indicates a significant increase in the risk of overdose death. Specifically, studies have shown that at this range, the risk increases to approximately two times (2x) the baseline risk of overdose.

This elevated risk is primarily due to the potential for respiratory depression caused by opioids, especially in higher doses. As MMEs increase, so does the likelihood of an individual encountering the adverse effects of opioids, including tolerance, physical dependence, and heightened chances of overdose. Guidelines often recommend cautious prescribing practices at this level, emphasizing regular monitoring and assessing the need for continued opioid therapy.

The other possible multipliers of risk (1x, 3x, and 4x) do not accurately represent the established data regarding overdose risks associated with the MME range of 50-99, overlooking the key evidence that identifies a doubling of the risk within this range.