Which cytochrome P-450 enzyme does CBD primarily interact with?

The correct choice identifies that CBD (cannabidiol) mainly interacts with the cytochrome P-450 enzymes CYP-2C19 and CYP-3A4. These enzymes are critically important for drug metabolism and play significant roles in the biotransformation of various substances within the liver.

CYP-3A4, in particular, is one of the most abundant enzymes in the human liver and is responsible for the metabolism of a large number of medications. When CBD is consumed, it can affect the activity of these enzymes, either increasing or decreasing the metabolism of co-administered drugs that are substrates of CYP-2C19 and CYP-3A4. This interaction is crucial for understanding drug-drug interactions, especially considering CBD's growing use in various therapeutic contexts.

Additionally, the presence of CBD can lead to altered plasma concentrations of drugs metabolized by these enzymes, which could potentially enhance effects or toxicity. This highlights the importance of awareness around CBD use for patients who are on other medications that are metabolized by CYP-2C19 and CYP-3A4.

In contrast, the other options involve enzymes that have different roles or are less commonly influenced by CBD. The focus on CYP-2C19 and CYP-3A