Which cytochrome P-450 enzyme does delta-9 THC interact with?

Delta-9 THC, the primary psychoactive component of cannabis, metabolizes primarily through the cytochrome P-450 enzyme system in the liver, specifically through several subtypes, notably CYP-3A4 and CYP-1A2. This interaction is crucial because it affects how THC is processed in the body, ultimately influencing its efficacy and duration of action.

CYP-3A4 is one of the most significant enzymes in drug metabolism and is responsible for a vast array of medications. When THC interacts with CYP-3A4, it can alter the metabolism of other drugs processed by the same enzyme, potentially leading to increased side effects or toxicity.

CYP-1A2 also plays a role in metabolizing THC but to a lesser extent. Its interaction with THC may likewise have implications for how THC and other substances are metabolized concurrently.

Understanding these interactions is essential for healthcare providers when considering drug interactions and tailoring pain management strategies, as they can influence both therapeutic effectiveness and safety. Therefore, the combination of these two enzymes makes the answer encompassing both significant.