Which NSAID is known to inhibit preterm labor?

Indomethacin is recognized for its ability to inhibit preterm labor due to its mechanism of action as a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting the production of prostaglandins, which play a crucial role in initiating labor. Prostaglandins stimulate uterine contractions, so by reducing their synthesis, indomethacin can effectively postpone or prevent preterm labor in certain cases.

This property makes indomethacin particularly useful in obstetric settings where managing preterm labor is critical. Its effectiveness has been documented in clinical studies, further solidifying its role in this indication.

In contrast, other NSAIDs listed, while effective for pain relief and inflammation, do not have the same established efficacy in inhibiting preterm labor. For example, naproxen, diclofenac, and ketorolac are primarily used for their analgesic and anti-inflammatory properties but lack the specific pharmacological impact on labor inhibition that indomethacin provides.