Which of the following NSAIDs has the highest cox1:cox2 ratio?

Flurbiprofen is known for its relatively high selectivity for COX-1 compared to COX-2, making it a non-steroidal anti-inflammatory drug (NSAID) that exhibits a higher COX-1 to COX-2 ratio. This characteristic is important because COX-1 is associated with the production of protective gastric mucosa and platelet function, while COX-2 is primarily involved in the inflammatory response. Therefore, medications with high COX-1 selectivity like flurbiprofen can lead to increased risks of gastrointestinal side effects but may be beneficial in conditions where COX-1's role is desired.

In contrast, medications like meloxicam, diclofenac, and celecoxib tend to have varying degrees of COX-2 selectivity, which often results in fewer gastrointestinal side effects but can also influence their overall efficacy in pain management. Meloxicam possesses some COX-2 selectivity but is not as pronounced as flurbiprofen’s preference for COX-1. Diclofenac shows a more balanced inhibition but also leans towards COX-2 inhibition. Celecoxib is specifically designed to be COX-2 selective, minimizing COX-1 involvement.

Thus,