Which of the following NSAIDs should be avoided when taking aspirin?

Indomethacin should be avoided when taking aspirin due to the potential interaction that increases the risk of gastrointestinal (GI) complications. Indomethacin is a potent nonsteroidal anti-inflammatory drug (NSAID) that can cause increased GI irritation, and combining it with aspirin, which also has anticoagulant properties, can exacerbate these risks. Additionally, indomethacin may interfere with the platelet inhibitory effect of aspirin, diminishing its cardiac protective benefits.

The other NSAIDs listed—nabumetone, meloxicam, and celecoxib—may have different safety profiles when used concurrently with aspirin. They do not typically pose the same level of concern regarding bleeding and GI risks when compared to indomethacin. This makes indomethacin particularly important to avoid in this context, emphasizing the significance of carefully considering drug interactions and side effects in pain management strategies.