Which opioid is known for having a high potential for overdose at a lower MME?

Fentanyl is recognized for having a high potential for overdose even at lower morphine milligram equivalents (MME) due to its potency. It is approximately 50 to 100 times more powerful than morphine, meaning that a much smaller dose can result in significant effects, including respiratory depression, which can be fatal. This characteristic is particularly concerning because it can lead to misuse and accidental overdose, especially in individuals who may not be tolerant to opioids. The narrow therapeutic window of fentanyl makes dosing particularly critical, as even slight deviations can result in severe adverse effects. This contributes to its high risk of overdose compared to other opioids, which generally have a higher threshold for toxicity relative to their analgesic effects.